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Article

Slow chloroguanide metabolism in Tanzanians compared with white subjects and Asian subjects confirms a decreased CYP2C19 activity in relation to genotype.

Clinical pharmacology and therapeutics - 1 Aug 2000

Herrlin K, Massele A Y, Rimoy G, Alm C, Rais M, Ericsson O, Bertilsson L, Gustafsson L L

Abstract excerpt

BACKGROUND: We have previously found decreased CYP2C19 activity in Tanzanians tested with mephenytoin and omeprazole in relation to genotype when compared with white and Asian subjects. OBJECTIVE: We investigated the impact of CYP2C19 genotype and phenotype on chloroguanide (INN, proguanil) metab...

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Source

Identifiers

PMID: 10976550
DOI: 10.1067/mcp.2000.108583

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10976550-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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