Article
Correlation between omeprazole hydroxylase and CYP2C19 genotype in North Indians.
European journal of clinical pharmacology - 1 Nov 2001
Lamba J K, Dhiman R K, Singh R, Kohli K K
Abstract excerpt
OBJECTIVE: To comprehend the correlation between the in vitro activity of hepatic omeprazole (OMZ) hydroxylase and genotype of North Indians with respect to CYP2C19. METHODS: Microsomes were prepared from the livers of 15 North Indians. Assay of OMZ hydroxylase was performed by incubating the microsomes with OMZ in the presence of reduced nicotinamide adenine dinucleotide phosphate (NADPH). The 5-OH-OMZ formed...
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