CYP2C19 genotype and phenotype determined by omeprazole in a Korean population.

doi:10.1097/00008571-199612000-00008

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Article

CYP2C19 genotype and phenotype determined by omeprazole in a Korean population.

Pharmacogenetics - 1 Dec 1996

Roh H K, Dahl M L, Tybring G, Yamada H, Cha Y N, Bertilsson L

Abstract excerpt

Omeprazole (20 mg orally) was given to 103 healthy Korean subjects and blood was taken 3 h after administration. The plasma concentration ratio of omeprazole and hydroxyomeprazole, used as an index of CYP2C19 activity, was bimodally distributed. Thirteen subjects (12.6%) were identified as poor m...

Topics

Administration, Oral
Adult
Alleles
Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP2C19
Cytochrome P-450 Enzyme System
Female
Gene Frequency
Genotype
Humans
Korea
Male
Mixed Function Oxygenases
Omeprazole
Phenotype

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