Article
CYP2C19 genotype and phenotype determined by omeprazole in a Korean population.
Pharmacogenetics - 1 Dec 1996
Roh H K, Dahl M L, Tybring G, Yamada H, Cha Y N, Bertilsson L
Abstract excerpt
Omeprazole (20 mg orally) was given to 103 healthy Korean subjects and blood was taken 3 h after administration. The plasma concentration ratio of omeprazole and hydroxyomeprazole, used as an index of CYP2C19 activity, was bimodally distributed. Thirteen subjects (12.6%) were identified as poor metabolizers (PMs) with an omeprazole hydroxylation ratio of 6.95 or higher. Among the 206 CYP2C19 alleles, CYP2C19*2...
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