Phenocopies of poor metabolizers of omeprazole caused by liver disease and drug treatment.

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Article

Phenocopies of poor metabolizers of omeprazole caused by liver disease and drug treatment.

Journal of hepatology - 1 Sept 1995

Rost K L, Brockmöller J, Esdorn F, Roots I

Abstract excerpt

BACKGROUND/AIMS: The kinetics of omeprazole and its primary metabolites 5'-hydroxyomeprazole and omeprazole sulfone were studied in healthy volunteers to evaluate omeprazole as a probe drug for the S-mephenytoin hydroxylase (CYP2C19) polymorphism. The plasma metabolic ratio obtained from the conc...

Topics

Administration, Oral
Adolescent
Adult
Aged
Aged, 80 and over
Analysis of Variance
Anti-Ulcer Agents
Anticonvulsants
Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP2C19
Cytochrome P-450 Enzyme System
Female
Genotype
Humans
Liver Diseases
Male
Mephenytoin
Middle Aged

Source

Open in PubMed

Identifiers

PMID: 8550990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8550990-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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