Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Improving CYP2C19 phenotyping using stereoselective omeprazole and 5-hydroxy-omeprazole metabolic ratios.

Basic & clinical pharmacology & toxicology - 1 Dec 2024

Abouir Kenza, Varesio Emmanuel, Déglon Julien, Samer Caroline, Daali Youssef

Abstract excerpt

Omeprazole (OME) is a CYP2C19 phenotyping probe, marketed as a racemic (S)/(R) mixture or as an S-enantiomer. Both CYP2C19 and CYP3A4 enzymes mediate (R)-OME hydroxylation to (R)-5-hydroxyomeprazole, while (S)-OME is exclusively hydroxylated via CYP2C19. This study investigates OME and its 5-hydroxymetabolite enantiomers' pharmacokinetics using data from two studies involving healthy volunteers. In Study A,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 2-Pyridinylmethylsulfinylbenzimidazoles
Share to Fluvoxamine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Healthy Volunteers

Share to Hydroxylation

Share to Omeprazole

Share to Proton Pump Inhibitors

Share to Stereoisomerism

Share to Voriconazole

Source

Open in PubMed Open full text

Identifiers

PMID: 39385496
DOI: 10.1111/bcpt.14095
PMCID: PMC11617642

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Improving CYP2C19 phenotyping using stereoselective omeprazole and 5-hydroxy-omeprazole metabolic ratios.PMID 39385496Read ↗

Hydroxylation of R(+)- and S(-)-omeprazole after racemic dosing are different among the CYP2C19 genotypes.Semantic proximity Read ↗

The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: a population study.Semantic proximity Read ↗

The (R)-omeprazole hydroxylation index reflects CYP2C19 activity in healthy Japanese volunteers.Semantic proximity Read ↗

Efavirenz-mediated induction of omeprazole metabolism is CYP2C19 genotype dependent.Semantic proximity Read ↗

Phenocopies of poor metabolizers of omeprazole caused by liver disease and drug treatment.Semantic proximity Read ↗

Chiral assay of omeprazole and metabolites and its application to a pharmacokinetics related to CYP2C19 genotypes.Semantic proximity Read ↗

Stereospecific analysis of omeprazole in human plasma as a probe for CYP2C19 phenotype.Semantic proximity Read ↗

Phenoconversion Due to Drug-Drug Interactions in CYP2C19 Genotyped Healthy Volunteers.Semantic proximity Read ↗

The role of cytochrome P2C19 in R-warfarin pharmacokinetics and its interaction with omeprazole.Semantic proximity Read ↗

Correspondence between the CYP2C19 and CYP3A4 genotypes with the inferred metabolizer phenotype by omeprazole administration in Mexican healthy children.Semantic proximity Read ↗

Comparative pharmacokinetics of Omeprazole and its metabolites in poor and extensive metabolizer Pakistani healthy volunteers and a review of different studies.Semantic proximity Read ↗

The impact of CYP2C19 genotype on phenoconversion by concomitant medicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.