Article
Family-based association study of cytotoxic T-lymphocyte antigen-4 with susceptibility to Graves' disease in Han population of Taiwan.
Genes and immunity - 1 Mar 2008
Chen P-L, Fann C S-J, Chang C-C, Wu I-L, Chiu W-Y, Lin C-Y, Yang W-S, Chang T-C
Abstract excerpt
Graves' disease (GD) is a common organ-specific autoimmune disorder inherited as a complex trait. Although there has not been consensus regarding the genuine susceptibility alleles, many population-based genetic studies showed association of the cytotoxic T-lymphocyte antigen-4 (CTLA4) gene with GD. In contrast, evidence utilizing family-based studies came only from the Caucasian population. Here we performed a...
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