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Article

Comprehensive genotyping in two homogeneous Graves' disease samples reveals major and novel HLA association alleles.

PloS one - 28 Jan 2011

Chen Pei-Lung, Fann Cathy Shen-Jang, Chu Chen-Chung, Chang Chien-Ching, Chang Su-Wei, Hsieh Hsin-Yi, Lin Marie, Yang Wei-Shiung, Chang Tien-Chun

Abstract excerpt

BACKGROUND: Graves' disease (GD) is the leading cause of hyperthyroidism and thyroid eye disease inherited as a complex trait. Although geoepidemiology studies showed relatively higher prevalence of GD in Asians than in Caucasians, previous genetic studies were contradictory concerning whether and/or which human leukocyte antigen (HLA) alleles are associated with GD in Asians. METHODOLOGY/PRINCIPAL FINDINGS: We...

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Identifiers

PMID: 21307958
DOI: 10.1371/journal.pone.0016635
PMCID: PMC3030609

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Source receipt: pubmed, retrieved 7 Sept 2026.

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