Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Decreased susceptibility of peripheral blood mononuclear cells from individuals heterozygous for a mutant CCR5 allele to HIV infection.

Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association - 1 Oct 1998

Kim A, Pettoello-Mantovani M, Goldstein H

Abstract excerpt

OBJECTIVE: Individuals homozygous for a deletion in the CCR5 gene (CCR5delta32/CCR5delta32) are resistant to HIV infection, indicating that this particular chemokine receptor plays a crucial role in the initiation of in vivo HIV infection. We investigated the effect of the heterozygote genotype (CCR5/CCR5delta32) on susceptibility of peripheral blood mononuclear cells (PBMC) to HIV infection. DESIGN: Sensitivity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Genotype

Share to Heterozygote

Share to HIV Infections

Share to Infant

Source

Identifiers

PMID: 9768623
DOI: 10.1097/00042560-199810010-00007

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decreased susceptibility of peripheral blood mononuclear cells from individuals heterozygous for a mutant CCR5 allele to HIV infection.PMID 9768623Read ↗

Homozygous and heterozygous CCR5-Delta32 genotypes are associated with resistance to HIV infection.Semantic proximity Read ↗

Role of the CCR5 delta 32 allele in resistance to HIV-1 infection in west Africa.Semantic proximity Read ↗

Prevalence of the CCR5Delta32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection.Semantic proximity Read ↗

CCR5Delta32 genotypes in a German HIV-1 seroconverter cohort and report of HIV-1 infection in a CCR5Delta32 homozygous individual.Semantic proximity Read ↗

Frequency of the HIV-protective CC chemokine receptor 5-Delta32/Delta32 genotype is increased in hepatitis C.Semantic proximity Read ↗

Reduced HIV-1 infectability of CD4+ lymphocytes from exposed-uninfected individuals: association with low expression of CCR5 and high production of beta-chemokines.Semantic proximity Read ↗

Phenotypic expressions of CCR5-delta32/delta32 homozygosity.Semantic proximity Read ↗

The coreceptor mutation CCR5Delta32 influences the dynamics of HIV epidemics and is selected for by HIV.Semantic proximity Read ↗

HIV-1 Infection in Persons Homozygous for CCR5-Δ32 Allele: The Next Case and the Review.Semantic proximity Read ↗

Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis.Semantic proximity Read ↗

Homozygous delta 32 deletion of the CCR-5 chemokine receptor gene in an HIV-1-infected patient.Semantic proximity Read ↗

Decreased HIV type 1 transcription in CCR5-Δ32 heterozygotes during suppressive antiretroviral therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.