Article
Decreased susceptibility of peripheral blood mononuclear cells from individuals heterozygous for a mutant CCR5 allele to HIV infection.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association - 1 Oct 1998
Kim A, Pettoello-Mantovani M, Goldstein H
Abstract excerpt
OBJECTIVE: Individuals homozygous for a deletion in the CCR5 gene (CCR5delta32/CCR5delta32) are resistant to HIV infection, indicating that this particular chemokine receptor plays a crucial role in the initiation of in vivo HIV infection. We investigated the effect of the heterozygote genotype (...
Topics
- Alleles
- Cells, Cultured
- Disease Progression
- Gene Deletion
- Genotype
- HIV Infections
- HIV-1
- Heterozygote
- Humans
- Immunity, Innate
- Infant
- Leukocytes, Mononuclear
- Receptors, CCR5