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Article

Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis.

PloS one - 1 Jan 2012

Liu Sijie, Kong Chuijin, Wu Jie, Ying Hao, Zhu Huanzhang

Abstract excerpt

BACKGROUND: So far, many studies have investigated the distribution of CCR5 genotype between HIV-1 infected patients and uninfected people. However, no definite results have been put forward about whether heterozygosity for a 32-basepair deletion in CCR5 gene (CCR5-Δ32) can affect HIV-1 susceptibility. METHODS: We performed a meta-analysis of 18 studies including more than 12000 subjects for whom the CCR5-Δ32...

Topics

Female
Genetic Association Studies
Genetic Predisposition to Disease
HIV Infections
HIV-1
Heterozygote
Humans
Male
Polymorphism, Genetic
Receptors, CCR5
Sequence Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 22496885
DOI: 10.1371/journal.pone.0035020
PMCID: PMC3320650

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis.PMID 22496885Read ↗

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