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Article

Decreased HIV type 1 transcription in CCR5-Δ32 heterozygotes during suppressive antiretroviral therapy.

The Journal of infectious diseases - 1 Dec 2014

Wang Charlene, Abdel-Mohsen Mohamed, Strain Matthew C, Lada Steven M, Yukl Steven, Cockerham Leslie R, Pilcher Christopher D, Hecht Frederick M, Sinclair Elizabeth, Liegler Teri, Richman Douglas D, Deeks Steven G, Pillai Satish K

Abstract excerpt

Individuals who are heterozygous for the CCR5-Δ32 mutation provide a natural model to examine the effects of reduced CCR5 expression on human immunodeficiency virus (HIV) persistence. We evaluated the HIV reservoir in 18 CCR5-Δ32 heterozygotes and 54 CCR5 wild-type individuals during suppressive antiretroviral therapy. Cell-associated HIV RNA levels (P=.035), RNA to DNA transcriptional ratios (P=.013), and...

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Share to Antiretroviral Therapy, Highly Active
Share to CD4 Lymphocyte Count

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4-Positive T-Lymphocytes

Share to CD8-Positive T-Lymphocytes

Share to Gene Expression Regulation, Viral

Share to HIV Infections

Share to Receptors, CCR5

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Source

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Identifiers

PMID: 24935955
DOI: 10.1093/infdis/jiu338
PMCID: PMC4271057

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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