Article
HIV-1 Infection in Persons Homozygous for CCR5-Δ32 Allele: The Next Case and the Review.
AIDS reviews - 1 Dec 2017
Smoleń-Dzirba Joanna, Rosińska Magdalena, Janiec Janusz, Beniowski Marek, Cycoń Mariusz, Bratosiewicz-Wąsik Jolanta, Wąsik Tomasz J
Abstract excerpt
CC-chemokine receptor 5 serves as the coreceptor for the HIV-1 R5 strains, which are responsible for the majority of HIV transmissions. A deletion of 32 nucleotides in the gene encoding this receptor (termed CCR5-Δ32) leads to the suppression of CC-chemokine receptor 5 presentation at the cell surface, thus impeding process of HIV entry into the cell. Individuals homozygous for the CCR5-Δ32 allele are resistant...
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