Article
Frequency of the HIV-protective CC chemokine receptor 5-Delta32/Delta32 genotype is increased in hepatitis C.
Gastroenterology - 1 Jun 2002
Woitas Rainer P, Ahlenstiel Golo, Iwan Agathe, Rockstroh Jürgen K, Brackmann Hans H, Kupfer Bernd, Matz Bertfried, Offergeld Ruth, Sauerbruch Tilman, Spengler Ulrich
Abstract excerpt
BACKGROUND & AIMS: A homozygous 32-base pair deletion in the CCR5 gene (CCR5-Delta32) protects against human immunodeficiency virus infection (HIV). However, the role of this mutation in other infections, such as hepatitis C virus (HCV) infection, has not been defined. METHODS: We determined the frequency of the CCR5-Delta32 mutation by polymerase chain reaction in anti-HCV(+) (n = 153), anti-HIV(+) (n = 102),...
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