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Article

The coreceptor mutation CCR5Delta32 influences the dynamics of HIV epidemics and is selected for by HIV.

Proceedings of the National Academy of Sciences of the United States of America - 28 Aug 2001

Sullivan A D, Wigginton J, Kirschner D

Abstract excerpt

We explore the impact of a host genetic factor on heterosexual HIV epidemics by using a deterministic mathematical model. A protective allele unequally distributed across populations is exemplified in our models by the 32-bp deletion in the host-cell chemokine receptor CCR5, CCR5Delta32. Individuals homozygous for CCR5Delta32 are protected against HIV infection whereas those heterozygous for CCR5Delta32 have...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11517319
DOI: 10.1073/pnas.181325198
PMCID: PMC56941

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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