Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced HIV-1 infectability of CD4+ lymphocytes from exposed-uninfected individuals: association with low expression of CCR5 and high production of beta-chemokines.

Virology - 25 Apr 1998

Paxton W A, Liu R, Kang S, Wu L, Gingeras T R, Landau N R, Mackay C R, Koup R A

Abstract excerpt

We examined the human immunodeficiency virus type 1 infectability of CD4+ lymphocytes isolated from CCR5 wild-type individuals, individuals heterozygous for the delta32 allele of CCR5, and HIV-1-exposed but uninfected (EU) individuals who had CD4+ lymphocytes refractory to M-tropic viral replication. None of the EU individuals were found to be heterozygous for the delta32 allele. The CD4+ lymphocytes isolated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Membrane

Share to CCR5 gene

Share to Genotype

Share to HIV Infections

Share to Recombinant Proteins

Source

Identifiers

PMID: 9581779
DOI: 10.1006/viro.1998.9082

Genes

CCR5
MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced HIV-1 infectability of CD4+ lymphocytes from exposed-uninfected individuals: association with low expression of CCR5 and high production of beta-chemokines.PMID 9581779Read ↗

HIV-1 infectability of CD4+ lymphocytes with relation to beta-chemokines and the CCR5 coreceptor.Semantic proximity Read ↗

Persistence of dual-tropic HIV-1 in an individual homozygous for the CCR5 Delta 32 allele.Semantic proximity Read ↗

Decreased susceptibility of peripheral blood mononuclear cells from individuals heterozygous for a mutant CCR5 allele to HIV infection.Semantic proximity Read ↗

Viremic control and viral coreceptor usage in two HIV-1-infected persons homozygous for CCR5 Δ32.Semantic proximity Read ↗

Genetic and functional analysis of R5X4 human immunodeficiency virus type 1 envelope glycoproteins derived from two individuals homozygous for the CCR5delta32 allele.Semantic proximity Read ↗

CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro.Semantic proximity Read ↗

Role of CCR5 in infection of primary macrophages and lymphocytes by macrophage-tropic strains of human immunodeficiency virus: resistance to patient-derived and prototype isolates resulting from the delta ccr5 mutationSemantic proximity Read ↗

CCR5 genotypes in sexually active couples discordant for human immunodeficiency virus type 1 infection status.Semantic proximity Read ↗

Homozygous delta 32 deletion of the CCR-5 chemokine receptor gene in an HIV-1-infected patient.Semantic proximity Read ↗

Lack of infection in HIV-exposed individuals is associated with a strong CD8(+) cell noncytotoxic anti-HIV response.Semantic proximity Read ↗

CCR 5 expression, haplotype and immune activation in protection from infection in HIV ‐exposed uninfected individuals in HIV ‐serodiscordant relationshipsSemantic proximity Read ↗

HIV-1-infected long-term slow progressors heterozygous for delta32-CCR5 show significantly lower plasma viral load than wild-type slow progressors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.