Article
Homozygous delta 32 deletion of the CCR-5 chemokine receptor gene in an HIV-1-infected patient.
AIDS (London, England) - 1 Aug 1997
Balotta C, Bagnarelli P, Violin M, Ridolfo A L, Zhou D, Berlusconi A, Corvasce S, Corbellino M, Clementi M, Clerici M, Moroni M, Galli M
Abstract excerpt
BACKGROUND: Recent research has found that entry of non-syncytium-inducing (NSI), monocyte-macrophage-tropic HIV-1 isolates requires binding to both CD4 and CCR5 receptors, and that delta 32/delta 32 homozygous individuals are protected against infection. OBJECTIVE: To analyse the polymorphism of CCR-5 gene in HIV-1-infected and uninfected subjects. DESIGN AND METHODS: CCR-5 sequences were amplified by polymerase...
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