Article
Phenotypic expressions of CCR5-delta32/delta32 homozygosity.
Journal of acquired immune deficiency syndromes (1999) - 1 Sept 1999
Nguyêñ G T, Carrington M, Beeler J A, Dean M, Aledort L M, Blatt P M, Cohen A R, DiMichele D, Eyster M E, Kessler C M, Konkle B, Leissinger C, Luban N, O'Brien S J, Goedert J J, O'Brien T R
Abstract excerpt
OBJECTIVE: As blockade of CC-chemokine receptor 5 (CCR5) has been proposed as therapy for HIV-1, we examined whether the CCR5-delta32/delta32 homozygous genotype has phenotypic expressions other than those related to HIV-1. DESIGN: Study subjects were white homosexual men or men with hemophilia who were not infected with HIV-1. In this study, 15 CCR5-delta32/delta32 homozygotes were compared with 201 CCR5...
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