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Article

T cell recognition of major histocompatibility complex class II complexes with invariant chain processing intermediates.

The Journal of experimental medicine - 1 Nov 1995

Morkowski S, Goldrath A W, Eastman S, Ramachandra L, Freed D C, Whiteley P, Rudensky AYu

Abstract excerpt

Peptides from the lumenal portion of invariant chain (Ii) spanning residues 80-106 (class II-associated Ii peptide [CLIP]) are found in association with several mouse and human major histocompatibility complex (MHC) class II allelic variants in wild-type and presentation-deficient mutant cells. The ready detection of these complexes suggests that such an intermediate is essential to the MHC class II processing...

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Identifiers

PMID: 7595211
DOI: 10.1084/jem.182.5.1403
PMCID: PMC2192223

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Source receipt: pubmed, retrieved 7 Sept 2026.

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T cell recognition of major histocompatibility complex class II complexes with invariant chain processing intermediates.PMID 7595211Read ↗

T cell recognition of flanking residues of murine invariant chain-derived CLIP peptide bound to MHC class II.Semantic proximity Read ↗

Identification of residues in the class II-associated Ii peptide (CLIP) region of invariant chain that affect efficiency of MHC class II-mediated antigen presentation in an allele-dependent manner.Semantic proximity Read ↗

Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.Semantic proximity Read ↗

Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP).Semantic proximity Read ↗

Promiscuous binding of invariant chain-derived CLIP peptide to distinct HLA-I molecules revealed in leukemic cells.Semantic proximity Read ↗

Class II-associated invariant chain peptide-independent binding of invariant chain to class II MHC molecules.Semantic proximity Read ↗

An altered invariant chain protein with an antigenic peptide in place of CLIP forms SDS-stable complexes with class II alphabeta dimers and facilitates highly efficient peptide loading.Semantic proximity Read ↗

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides.Semantic proximity Read ↗

The CLIP-substituted invariant chain efficiently targets an antigenic peptide to HLA class II pathway in L cells.Semantic proximity Read ↗

Clip binds to HLA class II using methionine-based, allele-dependent motifs as well as allele-independent supermotifs.Semantic proximity Read ↗

I-Ag7 is subject to post-translational chaperoning by CLIP.Semantic proximity Read ↗

A general model of invariant chain association with class II major histocompatibility complex proteins.Semantic proximity Read ↗

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