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Article

Promiscuous binding of invariant chain-derived CLIP peptide to distinct HLA-I molecules revealed in leukemic cells.

PloS one - 1 Jan 2012

van Luijn Marvin M, van de Loosdrecht Arjan A, Lampen Margit H, van Veelen Peter A, Zevenbergen Adri, Kester Michel G D, de Ru Arnoud H, Ossenkoppele Gert J, van Hall Thorbald, van Ham S Marieke

Abstract excerpt

Antigen presentation by HLA class I (HLA-I) and HLA class II (HLA-II) complexes is achieved by proteins that are specific for their respective processing pathway. The invariant chain (Ii)-derived peptide CLIP is required for HLA-II-mediated antigen presentation by stabilizing HLA-II molecules before antigen loading through transient and promiscuous binding to different HLA-II peptide grooves. Here, we demonstrate...

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Share to Antigen Presentation
Share to Antigens, Differentiation, B-Lymphocyte

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Histocompatibility Antigens Class I

Share to Histocompatibility Antigens Class II

Share to HLA-A2 Antigen

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Source

Open in PubMed Open full text

Identifiers

PMID: 22563374
DOI: 10.1371/journal.pone.0034649
PMCID: PMC3338516

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Promiscuous binding of invariant chain-derived CLIP peptide to distinct HLA-I molecules revealed in leukemic cells.PMID 22563374Read ↗

Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.Semantic proximity Read ↗

Identification of residues in the class II-associated Ii peptide (CLIP) region of invariant chain that affect efficiency of MHC class II-mediated antigen presentation in an allele-dependent manner.Semantic proximity Read ↗

Clip binds to HLA class II using methionine-based, allele-dependent motifs as well as allele-independent supermotifs.Semantic proximity Read ↗

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A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligandsSemantic proximity Read ↗

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An altered invariant chain protein with an antigenic peptide in place of CLIP forms SDS-stable complexes with class II alphabeta dimers and facilitates highly efficient peptide loading.Semantic proximity Read ↗

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Complexes of Two Cohorts of CLIP Peptides and HLA-DQ2 of the Autoimmune DR3-DQ2 Haplotype Are Poor Substrates for HLA-DMSemantic proximity Read ↗

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