Article
The CLIP-substituted invariant chain efficiently targets an antigenic peptide to HLA class II pathway in L cells.
Human immunology - 1 Oct 1998
Fujii S, Senju S, Chen Y Z, Ando M, Matsushita S, Nishimura Y
Abstract excerpt
The presentation of antigenic peptides by major histocompatibility complex (MHC) class II to CD4+ T cells is crucial to initiate immune responses. We developed a new system for delivery of an antigenic peptide to the MHC class II pathway, using the invariant chain (Ii). We designed a mutated huma...
Topics
- Amino Acid Sequence
- Animals
- Antigen Presentation
- Antigens
- Antigens, Bacterial
- Antigens, Differentiation, B-Lymphocyte
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- CD4-Positive T-Lymphocytes
- Carrier Proteins
- Cells, Cultured
- Genes, MHC Class II
- HLA-DR Antigens
- HLA-DRB1 Chains
- Histocompatibility Antigens Class II
- Humans
- Lymphocyte Activation
- Mice