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Article

An enzyme-linked immunosorbent assay for host cell protein contaminants in recombinant PEGylated staphylokinase mutant SY161.

Journal of pharmaceutical and biomedical analysis - 1 Jun 2002

Wan Min, Wang Yunjuan, Rabideau Susan, Moreadith Randall, Schrimsher Jeff, Conn Greg

Abstract excerpt

Staphylokinase, a bacterially-derived protein which functions as a plasminogen activator, has potential utility as a human therapeutic for thrombotic disorders. A recombinant version of this protein, SY161, contains 13 amino acid substitutions designed to decrease immunogenicity, and has been covalently modified by crosslinking a 5 kDa polyethyleneglycol (PEG) group to the N-terminal region to prolong the drug...

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PMID: 12039638
DOI: 10.1016/s0731-7085(01)00712-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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