Five birds, one stone: Neutralization of α-hemolysin and 4 bi-component leukocidins of <i>Staphylococcus aureus</i> with a single human monoclonal antibody

Abstract excerpt

Staphylococcus aureus is a major human pathogen associated with high mortality. The emergence of antibiotic resistance and the inability of antibiotics to counteract bacterial cytotoxins involved in the pathogenesis of S. aureus call for novel therapeutic approaches, such as passive immunization with monoclonal antibodies (mAbs). The complexity of staphylococcal pathogenesis and past failures with single mAb...

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