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Article

Recombinant staphylokinase variants with altered immunoreactivity. III: Species variability of antibody binding patterns.

Circulation - 21 Jan 1997

Collen D, De Cock F, Demarsin E, Jenné S, Lasters I, Laroche Y, Warmerdam P, Jespers L

Abstract excerpt

BACKGROUND: The "charged cluster-to-alanine" substitution variants SakSTAR(K35A,E38A,K74A,E75A,R77A) and SakSTAR(K74A,E75A,R77A,E80A,D82A), previously identified as SakSTAR.M38 and SakSTAR.M89, respectively, induce less antibody formation in patients than wild-type recombinant staphylokinase (SakSTAR), but their specific activities are reduced by 50%. Therefore, the effect of the reversal of one or more of these...

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PMID: 9008464
DOI: 10.1161/01.cir.95.2.455

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