Article
Recombinant staphylokinase variants with altered immunoreactivity. III: Species variability of antibody binding patterns.
Circulation - 21 Jan 1997
Collen D, De Cock F, Demarsin E, Jenné S, Lasters I, Laroche Y, Warmerdam P, Jespers L
Abstract excerpt
BACKGROUND: The "charged cluster-to-alanine" substitution variants SakSTAR(K35A,E38A,K74A,E75A,R77A) and SakSTAR(K74A,E75A,R77A,E80A,D82A), previously identified as SakSTAR.M38 and SakSTAR.M89, respectively, induce less antibody formation in patients than wild-type recombinant staphylokinase (Sak...
Topics
- Animals
- Antibodies
- Antibodies, Monoclonal
- Blood
- Cricetinae
- Epitopes
- Fibrinolytic Agents
- Genetic Variation
- Humans
- Injections
- Metalloendopeptidases
- Mice
- Myocardial Infarction
- Papio
- Rabbits
- Recombinant Proteins
- Species Specificity