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Article

Structural correlates of a functional streptokinase antigenic epitope: serine 138 is an essential residue for antibody binding.

Journal of immunological methods - 15 Jan 2003

Parhami-Seren Behnaz, Seavey Matthew, Krudysz Jolanta, Tsantili Panayota

Abstract excerpt

We determined the pattern of cross-reactivity of a panel of anti-streptokinase (SK) monoclonal antibodies (mAbs) with SK variants in order to map the antigenic and functional epitope of SK. Comparison of the pattern of cross-reactivity of the anti-SK mAb A4.3 with SK variants and sequence alignments of SK variants and native (n) SK suggested that mutation of Ser 138 to Lys results in loss of binding of mAb A4.3...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12505715
DOI: 10.1016/s0022-1759(02)00435-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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