Immunologic and structural analysis of eight novel domain-deletion beta3 integrin peptides designed for detection of HPA-1 antibodies.

doi:10.1111/j.1538-7836.2008.02858.x

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Article

Immunologic and structural analysis of eight novel domain-deletion beta3 integrin peptides designed for detection of HPA-1 antibodies.

Journal of thrombosis and haemostasis : JTH - 1 Feb 2008

Stafford P, Ghevaert C, Campbell K, Proulx C, Smith G, Williamson L M, Ranasinghe E, Watkins N A, Huntington J A, Ouwehand W H

Abstract excerpt

BACKGROUND: The single-nucleotide polymorphism (SNP) rs5918 in the ITGB3 gene defines the human platelet antigen-1 (HPA-1) system encoding a Leu (HPA-1a) or Pro (HPA-1b) at position 33. HPA-1 antibodies are clinically the most relevant in the Caucasoid population, but detection currently requires alpha(IIb)beta3 integrin from the platelets of HPA-genotyped donors. OBJECTIVES: We set out to define the beta3...

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PMID: 18045240
DOI: 10.1111/j.1538-7836.2008.02858.x

Genes

ITGB3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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