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Article

Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs.

Development (Cambridge, England) - 1 Sept 2008

Jeong Juhee, Li Xue, McEvilly Robert J, Rosenfeld Michael G, Lufkin Thomas, Rubenstein John L R

Abstract excerpt

Dlx transcription factors are implicated in patterning the mammalian jaw, based on their nested expression patterns in the first branchial arch (primordium for jaw) and mutant phenotypes; inactivation of Dlx1 and Dlx2 (Dlx1/2-/-) causes defects in the upper jaw, whereas Dlx5/6(-/-) results in homeotic transformation of the lower jaw into upper jaw. Therefore, the 'Dlx codes' appear to regionalize the jaw...

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Identifiers

PMID: 18697905
DOI: 10.1242/dev.019778
PMCID: PMC4913551

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Source receipt: pubmed, retrieved 7 Sept 2026.

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