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Article

A comprehensive series of Irx cluster mutants reveals diverse roles in facial cartilage development.

Development (Cambridge, England) - 15 Aug 2021

Farmer D'Juan T, Patel Punam, Choi Rachelle, Liu Chih-Yu, Crump J Gage

Abstract excerpt

Proper function of the vertebrate skeleton requires the development of distinct articulating embryonic cartilages. Irx transcription factors are arranged in co-regulated clusters that are expressed in the developing skeletons of the face and appendages. IrxB cluster genes are required for the separation of toes in mice and formation of the hyoid joint in zebrafish, yet whether Irx genes have broader roles in...

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PMID: 34338288
DOI: 10.1242/dev.197244
PMCID: PMC8406535

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