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Article

Pex mRNA Is Localized in Developing Mouse Osteoblasts and Odontoblasts

1 Apr 1998

Abstract excerpt

Mutations in PEX, a phosphate-regulating gene with homology to endopeptidase on the X chromosome, were recently identified in patients with X-linked hypophosphatemia (XLH), an inherited disorder of phosphate homeostasis characterized by growth retardation and rachitic and osteomalacic bone disease. To understand the mechanism by which loss of PEX function elicits the mutant phenotype, a study of its mRNA...

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Identifiers

PMID: 9524191
DOI: 10.1177/002215549804600405

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pex mRNA Is Localized in Developing Mouse Osteoblasts and OdontoblastsPMID 9524191Read ↗

Cloning and sequencing of human PEX from a bone cDNA library: evidence for its developmental stage-specific regulation in osteoblasts.Semantic proximity Read ↗

Pex/PEX tissue distribution and evidence for a deletion in the 3' region of the Pex gene in X-linked hypophosphatemic mice.Semantic proximity Read ↗

Developmental Expression and Tissue Distribution of Phex Protein: Effect of the <i>Hyp</i> Mutation and Relationship to Bone MarkersSemantic proximity Read ↗

Evidence for Phex haploinsufficiency in murine X-linked hypophosphatemia.Semantic proximity Read ↗

X-linked hypophosphataemia: a homologous disorder in humans and mice.Semantic proximity Read ↗

The PEX gene: its role in X-linked rickets, osteomalacia, and bone mineral metabolism.Semantic proximity Read ↗

Osteocyte-Specific Monoclonal Antibody MAb OB7.3 Is Directed Against Phex ProteinSemantic proximity Read ↗

Genetic screening for X-linked hypophosphatemic mice and ontogenic characterization of the defect in the renal sodium-phosphate transporter.Semantic proximity Read ↗

Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression.Semantic proximity Read ↗

Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype.Semantic proximity Read ↗

1,25-(OH)2D3 down-regulates expression of Phex, a marker of the mature osteoblast.Semantic proximity Read ↗

Phex mutation causes overexpression of FGF23 in teeth.Semantic proximity Read ↗

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