Article
[p53 mutations and HPV infections in squamous epithelial carcinomas of the head-neck region. Long-term follow-up].
Mund-, Kiefer- und Gesichtschirurgie : MKG - 1 Jan 1998
Riethdorf S, Friedrich R E, Sühwold J, Ostwald C, Barten M, Gogacz P, Gundlach K K, Schlechte H, Becker J, Bregenzer T, Riethdorf L, Löning T
Abstract excerpt
Mutations of the p53 gene are the most commonly observed genetic alterations in malignant tumors and are often associated with a loss of the tumor suppressor function of the p53 protein. We have analyzed specimens of head and neck squamous cell carcinomas (HNSCC) from 110 patients for p53 gene mutations and 92 of them additionally for human papillomavirus (HPV) infection in order to evaluate the prognostic...
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