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Article

Expression of p53 and its homologues in primary and recurrent squamous cell carcinomas of the head and neck

27 Mar 2002

Abstract excerpt

The tumour-suppressor protein p53 belongs to a family that includes 2 structurally related proteins, p63 and p73. Because of their structural homology, it has been hypothesized that both homologues serve as "spare mechanisms" in p53 mutations to regulate the cell cycle by inducing apoptosis. We investigated the mutational and protein expression status of p53 in correlation to its homologues, p73 and p63, in...

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PMID: 11948487
DOI: 10.1002/ijc.10296

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