Article
Neutrophils deficient in PU.1 do not terminally differentiate or become functionally competent.
Blood - 1 Sept 1998
Anderson K L, Smith K A, Pio F, Torbett B E, Maki R A
Abstract excerpt
PU.1 is an ets family transcription factor that is expressed specifically in hematopoietic lineages. Through gene disruption studies in mice we have previously shown that the expression of PU.1 is not essential for early myeloid lineage or neutrophil commitment, but is essential for monocyte/macr...
Topics
- Animals
- Cell Differentiation
- Cells, Cultured
- Chemotaxis, Leukocyte
- Cytoplasmic Granules
- DNA-Binding Proteins
- Granulocyte Colony-Stimulating Factor
- Granulocyte-Macrophage Colony-Stimulating Factor
- Interferon Regulatory Factors
- Interleukin-8
- Macrophage Colony-Stimulating Factor
- Mice
- N-Formylmethionine Leucyl-Phenylalanine
- NADPH Oxidases
- Neutrophil Activation
- Neutrophils
- Phagocytosis
- Phenotype