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Article

Neutrophils deficient in PU.1 do not terminally differentiate or become functionally competent.

Blood - 1 Sept 1998

Anderson K L, Smith K A, Pio F, Torbett B E, Maki R A

Abstract excerpt

PU.1 is an ets family transcription factor that is expressed specifically in hematopoietic lineages. Through gene disruption studies in mice we have previously shown that the expression of PU.1 is not essential for early myeloid lineage or neutrophil commitment, but is essential for monocyte/macrophage development. We have also shown that PU.1-null (deficient) neutrophils have neutrophil morphology and express...

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Source

Identifiers

PMID: 9716585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neutrophils deficient in PU.1 do not terminally differentiate or become functionally competent.PMID 9716585Read ↗

Myeloid development is selectively disrupted in PU.1 null mice.Semantic proximity Read ↗

Reduced PU.1 expression underlies aberrant neutrophil maturation and function in β-thalassemia mice and patientsSemantic proximity Read ↗

PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors.Semantic proximity Read ↗

Differential regulation of primitive myelopoiesis in the zebrafish by Spi-1/Pu.1 and C/ebp1.Semantic proximity Read ↗

In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils.Semantic proximity Read ↗

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.Semantic proximity Read ↗

PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis.Semantic proximity Read ↗

Reduction in PU.1 activity results in a block to B-cell development, abnormal myeloid proliferation, and neonatal lethality.Semantic proximity Read ↗

Analysis of concentration-dependent functions of PU.1 in hematopoiesis using mouse models.Semantic proximity Read ↗

Mutations of the transcription factor PU.1 are not associated with acute lymphoblastic leukaemia.Semantic proximity Read ↗

Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-BSemantic proximity Read ↗

Heterozygous PU.1 mutations are associated with acute myeloid leukemia.Semantic proximity Read ↗

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