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Article

Mutations of the transcription factor PU.1 are not associated with acute lymphoblastic leukaemia.

British journal of cancer - 19 Jun 2006

Mueller B U, Pabst T, Hauser P, Gilliland G, Neuberg D, Tenen D G

Abstract excerpt

The transcription factor PU.1 plays a crucial role during normal haematopoiesis in both myeloid cells and B-lymphocytes. Mice with a disruption in both alleles of the PU.1 locus were found to lack macrophages and B cells and had delayed appearance of neutrophils. In addition, critical decrease of PU.1 expression is sufficient to cause acute myeloid leukaemia (AML) and lymphomas in mice. Recently, we reported that...

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Identifiers

PMID: 16735999
DOI: 10.1038/sj.bjc.6603198
PMCID: PMC2361337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutations of the transcription factor PU.1 are not associated with acute lymphoblastic leukaemia.PMID 16735999Read ↗

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Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha.Semantic proximity Read ↗

PU.1 is regulated by NF-kappaB through a novel binding site in a 17 kb upstream enhancer element.Semantic proximity Read ↗

Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukaemia.Semantic proximity Read ↗

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Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin diseaseSemantic proximity Read ↗

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