Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterozygous PU.1 mutations are associated with acute myeloid leukemia.

Blood - 1 Aug 2002

Mueller Beatrice U, Pabst Thomas, Osato Motomi, Asou Norio, Johansen Lisa M, Minden Mark D, Behre Gerhard, Hiddemann Wolfgang, Ito Yoshiaki, Tenen Daniel G

Abstract excerpt

The transcription factor PU.1 is required for normal blood cell development. PU.1 regulates the expression of a number of crucial myeloid genes, such as the macrophage colony-stimulating factor (M-CSF) receptor, the granulocyte colony-stimulating factor (G-CSF) receptor, and the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor. Myeloid cells derived from PU.1(-/-) mice are blocked at the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Leukemia, Myeloid
Share to Leukocytes, Mononuclear

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins

Share to Acute Disease

Share to Cell Differentiation

Share to Granulocytes

Share to Receptor, Macrophage Colony-Stimulating Factor

Share to Trans-Activators

Source

Identifiers

PMID: 12130514
DOI: 10.1182/blood.v100.3.998

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterozygous PU.1 mutations are associated with acute myeloid leukemia.PMID 12130514Read ↗

Mutations of the transcription factor PU.1 are not associated with acute lymphoblastic leukaemia.Semantic proximity Read ↗

Heterozygous deletion of the PU.1 locus in human AML.Semantic proximity Read ↗

PU.1 is regulated by NF-kappaB through a novel binding site in a 17 kb upstream enhancer element.Semantic proximity Read ↗

Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha.Semantic proximity Read ↗

Early aberrant DNA methylation events in a mouse model of acute myeloid leukemiaSemantic proximity Read ↗

A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.Semantic proximity Read ↗

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.Semantic proximity Read ↗

PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors.Semantic proximity Read ↗

One hundred thirty-four germ line PU.1 variants and the agammaglobulinemic patients carrying themSemantic proximity Read ↗

Analysis of concentration-dependent functions of PU.1 in hematopoiesis using mouse models.Semantic proximity Read ↗

PU.1 downregulation in murine radiation-induced acute myeloid leukaemia (AML): from molecular mechanism to human AMLSemantic proximity Read ↗

Myeloid development is selectively disrupted in PU.1 null mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.