Cytoplasmic retention of mutant tsp53 is dependent on an intermediate filament protein (vimentin) scaffold.

doi:10.1038/sj.onc.1202155

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Article

Cytoplasmic retention of mutant tsp53 is dependent on an intermediate filament protein (vimentin) scaffold.

Oncogene - 2 Jul 1998

Klotzsche O, Etzrodt D, Hohenberg H, Bohn W, Deppert W

Abstract excerpt

The temperature-sensitive mutant tsp53val135 accumulates in the cytoplasm of cells kept at the non-permissive temperature (39 degrees C), but is rapidly transported into the cell nucleus at the permissive temperature (30 degrees C). tsp53 thus may serve as a model for analysing cellular parameter...

Topics

Actins
Animals
Biological Transport
Cell Compartmentation
Cell Nucleus
Cytochalasin B
Cytoplasm
Cytoskeleton
Fluorescent Antibody Technique
Glioma
Mice
Mutation
Rats
Tubulin
Tumor Cells, Cultured
Tumor Suppressor Protein p53
Vimentin
Vinblastine

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