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Article

The cellular chromatin is an important target for SV40 large T antigen in maintaining the transformed phenotype.

Virology - 1 Feb 1990

Richter W, Deppert W

Abstract excerpt

To identify cellular targets of simian virus 40 large T antigen (SV40 large T) important for the maintenance of cellular transformation, we have compared biological properties of SV40 tsA58 mutant large T antigens expressed in cells of a matched pair of SV40 tsA58 N-type (temperature-sensitive) and A-type (temperature-insensitive) transformants of the normal rat fibroblast line F111 (D. Pintel et al., J. Virol....

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Identifiers

PMID: 2154889
DOI: 10.1016/0042-6822(90)90108-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The cellular chromatin is an important target for SV40 large T antigen in maintaining the transformed phenotype.PMID 2154889Read ↗

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Simian virus 40 large tumour antigen is produced but not expressed in revertant cell lines RD2005 and RXHO24.Semantic proximity Read ↗

SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation.Semantic proximity Read ↗

Generation of a temperature-sensitive cSRC.Semantic proximity Read ↗

Thermally inactivated simian virus 40 tsA58 mutant T antigen cannot initiate viral DNA replication in vitro.Semantic proximity Read ↗

Independent expression of the transforming amino-terminal domain of SV40 large I antigen from an alternatively spliced third SV40 early mRNA.Semantic proximity Read ↗

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