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Article

The cellular chromatin is an important target for SV40 large T antigen in maintaining the transformed phenotype.

Virology - 1 Feb 1990

Richter W, Deppert W

Abstract excerpt

To identify cellular targets of simian virus 40 large T antigen (SV40 large T) important for the maintenance of cellular transformation, we have compared biological properties of SV40 tsA58 mutant large T antigens expressed in cells of a matched pair of SV40 tsA58 N-type (temperature-sensitive) and A-type (temperature-insensitive) transformants of the normal rat fibroblast line F111 (D. Pintel et al., J. Virol....

Topics

Actins
Antigens, Polyomavirus Transforming
Cell Division
Cell Transformation, Viral
Chromatin
DNA, Viral
Hot Temperature
Mutation
Phenotype
Simian virus 40

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 2154889
DOI: 10.1016/0042-6822(90)90108-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2154889-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The cellular chromatin is an important target for SV40 large T antigen in maintaining the transformed phenotype.PMID 2154889Read ↗

Phenotype-specific phosphorylation of simian virus 40 tsA mutant large T antigens in tsA N-type and A-type transformants.Semantic proximity Read ↗

Functional interaction of nuclear transport-defective simian virus 40 large T antigen with chromatin and nuclear matrix.Semantic proximity Read ↗

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Simian virus 40 large tumour antigen is produced but not expressed in revertant cell lines RD2005 and RXHO24.Semantic proximity Read ↗

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Generation of a temperature-sensitive cSRC.Semantic proximity Read ↗

Thermally inactivated simian virus 40 tsA58 mutant T antigen cannot initiate viral DNA replication in vitro.Semantic proximity Read ↗

Independent expression of the transforming amino-terminal domain of SV40 large I antigen from an alternatively spliced third SV40 early mRNA.Semantic proximity Read ↗

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