Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Slow time-dependent cellular transformation induced at restrictive temperature by ts-src mutants.

Oncogene - 1 Aug 1992

David-Pfeuty T, Nouvian-Dooghe Y

Abstract excerpt

Cell lines infected with a temperature-sensitive Rous sarcoma virus have been widely used to study the temporal dynamics of various transformation parameters following downshift from the non-permissive temperature to the permissive temperature as it is considered that, at the non-permissive temperature, the infected cells exhibit the morphological and growth characteristics of normal cell whereas, at the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Avian Sarcoma Viruses
Share to Cell Line
Share to Cell Transformation, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, src

Share to Microscopy, Fluorescence

Share to Mutation

Share to Temperature

Source

Identifiers

PMID: 1321405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Slow time-dependent cellular transformation induced at restrictive temperature by ts-src mutants.PMID 1321405Read ↗

Loss of transformed phenotype upon senescence of Rous sarcoma virus-infected chicken neuroretinal cells.Semantic proximity Read ↗

Functions of the v-Src protein tyrosine kinase.Semantic proximity Read ↗

Mutations in v-Src SH3 and catalytic domains that jointly confer temperature-sensitive transformation with minimal temperature-dependent changes in cellular tyrosine phosphorylation.Semantic proximity Read ↗

Role of Gas1 down-regulation in mitogenic stimulation of quiescent NIH3T3 cells by v-Src.Semantic proximity Read ↗

The cellular chromatin is an important target for SV40 large T antigen in maintaining the transformed phenotype.Semantic proximity Read ↗

A mutation in the catalytic domain of pp60v-src is responsible for the host- and temperature-dependent phenotype of the Rous sarcoma virus mutant tsLA33-1.Semantic proximity Read ↗

v-src-induced cell shape changes in rat fibroblasts require new gene transcription and precede loss of focal adhesions.Semantic proximity Read ↗

Phenotype-specific phosphorylation of simian virus 40 tsA mutant large T antigens in tsA N-type and A-type transformants.Semantic proximity Read ↗

Mitogenesis by v-Src: fluctuations throughout G1 of classical immediate early AP-1 and mitogen-activated protein kinase responses that parallel the need for the oncoprotein.Semantic proximity Read ↗

Characterization of avian retroviruses carrying activated transforming human c-src genes and of steps involved in expression of activated src-PKases in vitro.Semantic proximity Read ↗

Generation of a temperature-sensitive cSRC.Semantic proximity Read ↗

Abrogation of wild-type p53 mediated growth-inhibition by nuclear exclusion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.