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Article

Human major HSP70 protein complements the localization and functional defects of cytoplasmic mutant SV40 T antigen in Swiss 3T3 mouse fibroblast cells.

Genes & development - 1 Dec 1991

Jeoung D I, Chen S, Windsor J, Pollack R E

Abstract excerpt

The CT3 cytoplasmic localization mutant of SV40 T antigen is neither properly transported to the nucleus nor is it functional in rodent cells. Human precrisis cells are able to complement this mutation, as they are fully transformed by CT3 with wild-type efficiency. The human-specific factors responsible for this species-specific difference in response to CT3 were localized to human chromosome 6 by synteny in a...

Topics

3T3 Cells
Animals
Antigens, Polyomavirus Transforming
Biological Transport
Cloning, Molecular
Genetic Complementation Test
Heat-Shock Proteins
Humans
Mice
Mutation
Species Specificity

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Identifiers

PMID: 1748281
DOI: 10.1101/gad.5.12a.2235

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1748281-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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