Article
Correlation between the conformational phenotype of p53 and its subcellular location.
Oncogene - 1 Jul 1992
Zerrahn J, Deppert W, Weidemann D, Patschinsky T, Richards F, Milner J
Abstract excerpt
In order to obtain insight into the parameters determining the subcellular localization of mutant and wild-type forms of p53, we analysed the subcellular distribution of p53 in four Balb/c mouse-derived cell lines ranging in their cellular phenotypes from normal (3T3), via minimal transformant (T3T3), to maximally transformed (3T3tx, Meth A). Epitope mapping showed the p53 proteins in 3T3 and in T3T3 cells to be...
Topics
- Animals
- Cell Fractionation
- Cell Line
- Cell Nucleus
- Half-Life
- Heat-Shock Proteins
- Mice
- Mice, Inbred BALB C
- Mutation
- Phenotype
- Protein Binding
- Protein Conformation