Article
Absence of p53 mutations in benign and pre-malignant male genital lesions with over-expressed p53 protein.
International journal of cancer - 31 Aug 1998
Castrén K, Vähäkangas K, Heikkinen E, Ranki A
Abstract excerpt
Mutations of the tumor-suppressor gene p53 are common in epithelial tumors. Clonal mutations of p53 have been found in cervical and vulvar carcinomas negative for human papillomavirus (HPV), though at least in cervical cancer HPV infection and p53 mutations are not mutually exclusive. We have previously shown that about 40% of male genital warts and bowenoid papulosis lesions exhibit immunohistochemically...
Topics
- Biopsy
- Bowen's Disease
- Carcinoma in Situ
- Carcinoma, Squamous Cell
- Condylomata Acuminata
- Exons
- Female
- Genes, p53
- Genital Diseases, Male
- Genital Neoplasms, Male
- Humans
- Male
- Mutation
- Papillomaviridae
- Precancerous Conditions
- Skin Neoplasms
- Tumor Suppressor Protein p53
- Uterine Cervical Neoplasms