Article
Mutations of the p53 gene are not detectable in human testicular tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 1994
Fleischhacker M, Strohmeyer T, Imai Y, Slamon D J, Koeffler H P
Abstract excerpt
The tumor suppressor gene p53 is the most frequently mutated gene in human cancer. We have used polymerase chain reaction-single-strand conformation polymorphism analysis and sequencing to examine the status of the p53 gene in human testicular cancers of various histologies. We were unable to find in 40 samples and four cell lines any mutations in the regions of this gene (exons 5 through 8) that are usually...
Topics
- Base Sequence
- Blotting, Northern
- DNA, Neoplasm
- Exons
- Gene Amplification
- Gene Expression
- Genes, p53
- Humans
- Male
- Molecular Sequence Data
- Mutation