Article
p53 gene mutations in human epithelial skin cancers.
Oncogene - 1 Mar 1993
Molès J P, Moyret C, Guillot B, Jeanteur P, Guilhou J J, Theillet C, Basset-Sèguin N
Abstract excerpt
In the present study we analysed 38 epithelial skin cancers, 19 basal cell carcinomas (BCCs), 13 squamous cell carcinomas (SCCs) and six Bowen diseases (BwDs), using a combination of polymerase chain reaction (PCR) and single-stranded conformation polymorphism (SSCP) techniques for the presence of p53 and RAS gene mutations. Whereas 48% (9/19) of the BCCs tested presented a mutated p53 gene, the frequency was...
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