Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HPV-negative penile squamous cell carcinoma: disruptive mutations in the TP53 gene are common.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2017

Kashofer Karl, Winter Elke, Halbwedl Iris, Thueringer Andrea, Kreiner Marisa, Sauer Stefan, Regauer Sigrid

Abstract excerpt

The majority of penile squamous cell carcinomas is caused by transforming human papilloma virus (HPV) infection. The etiology of HPV-negative cancers is unclear, but TP53 mutations have been implicated. Archival tissues of 108 invasive squamous cell carcinoma from a single pathology institution in a low-incidence area were analyzed for HPV-DNA and p16ink4a overexpression and for TP53 mutations by ion torrent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to Genotype

Share to Mutation

Share to Papillomaviridae

Share to Penile Neoplasms

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 28387325
DOI: 10.1038/modpathol.2017.26

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HPV-negative penile squamous cell carcinoma: disruptive mutations in the TP53 gene are common.PMID 28387325Read ↗

Analysis of full coding sequence of the TP53 gene in invasive vulvar cancers: Implications for therapy.Semantic proximity Read ↗

Single-cell Atlas of Penile Cancer Reveals TP53 Mutations as a Driver of an Aggressive Phenotype, Irrespective of Human Papillomavirus Status, and Provides Clues for Treatment Personalization.Semantic proximity Read ↗

Pathogenesis of Penile Squamous Cell Carcinoma: Molecular Update and Systematic Review.Semantic proximity Read ↗

TERT promoter mutations in penile squamous cell carcinoma: high frequency in non-HPV-related type and association with favorable clinicopathologic features.Semantic proximity Read ↗

Different Mutational Landscapes in Human Papillomavirus-Induced and Human Papillomavirus-Independent Invasive Penile Squamous Cell Cancers.Semantic proximity Read ↗

Molecular characterization of squamous cell carcinoma of the anal canalSemantic proximity Read ↗

Whole-Exome Sequencing of Vulvar Squamous Cell Carcinomas Reveals an Impaired Prognosis in Patients With TP53 Mutations and Concurrent CCND1 Gains.Semantic proximity Read ↗

TERT Promoter Mutations in Penile Squamous Cell Carcinoma: High Frequency in Non-HPV-related Type and Association With Favorable Clinicopathologic FeaturesSemantic proximity Read ↗

Somatic Mutation Profiling in Premalignant Lesions of Vulvar Squamous Cell Carcinoma.Semantic proximity Read ↗

TP53 mutations in head and neck cancer.Semantic proximity Read ↗

Targeted next-generation sequencing of TP53 in oral tongue carcinoma from non-smokers.Semantic proximity Read ↗

Identification of somatic gene mutations in penile squamous cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.