Article
The state of the p53 gene in human papillomavirus (HPV)-positive and HPV-negative genital precancer lesions and carcinomas as determined by single-strand conformation polymorphism analysis and sequencing.
Anticancer research - 1 Jan 2000
Kurvinen K, Tervahauta A, Syrjänen S, Chang F, Syrjänen K
Abstract excerpt
Human papillomavirus (HPV) is frequently associated with cervical carcinoma. Inactivation of the p53 tumor suppressor gene product by binding to the HPV encoded E6 protein is considered as an important pathway for malignant progress in HPV-infected cells. In contrast, mutations of the p53 gene have been found in HPV-negative cervical carcinoma cells. To evaluate the involvement of p53 inactivation for the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.