Absence of p53 gene mutations in cutaneous melanoma.

Abstract excerpt

Mutations in the p53 tumor suppressor gene are a common finding in many human malignancies. These mutations have been shown to inactivate the p53 protein and sometimes confer an oncogenic potential to the mutated gene. Type and pattern of p53 mutations may give clues to the tumor etiology, for ex...

Topics

• Base Sequence
• Carcinoma, Squamous Cell
• Exons
• Genes, p53
• Humans
• Melanoma
• Molecular Sequence Data
• Mutation
• Neoplasm Metastasis
• Polymerase Chain Reaction
• Sequence Analysis
• Skin Neoplasms
• Ultraviolet Rays