Article
p53 expression is rare in cutaneous melanomas.
The American Journal of dermatopathology - 1 Aug 1995
Saenz-Santamaría M C, McNutt N S, Bogdany J K, Shea C R
Abstract excerpt
Alterations in the tumor-suppressor gene p53 are common in many types of human malignancies, but the potential role of p53 in the pathogenesis of cutaneous melanoma is controversial. The gene product, p53 protein, is normally present in very small amounts in noncancerous tissues. Missense mutations lead to accumulation of mutant p53 in the cells, which makes it detectable immunohistochemically in many cancers....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.