Article
p53 gene mutations in skin cancers with underlying disorders.
Journal of dermatological science - 1 May 1995
Kanekura T, Kanzaki T, Kanekura S, Kawahara K, Nakashima T, Kitajima I, Maruyama I
Abstract excerpt
Mutations in p53, a tumor suppressor gene, are one of the most common genetic lesions of human cancers. The relationship between p53 gene mutation and ultraviolet (UV) light has been demonstrated in skin cancers of sun-exposed sites. In this study, genomic DNA from 12 skin cancers was screened for mutations in exons 5 to 9 of this gene using the polymerase chain reaction--single strange configuration polymorphism...
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