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Article

Base-specific sequences that bias somatic hypermutation deduced by analysis of out-of-frame human IgVH genes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1998

Dunn-Walters D K, Dogan A, Boursier L, MacDonald C M, Spencer J

Abstract excerpt

Somatic hypermutation introduces mutations into IgV genes during affinity maturation of the B cell response. Mutations are introduced nonrandomly, and are generally targeted to the complementarity determining regions (CDRs). Subsequent selection against mutations that result in lower affinity or nonfunctional Ig increases the relative number of mutations in the CDRs. Investigation of somatic hypermutation is...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9498777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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