Base-specific sequences that bias somatic hypermutation deduced by analysis of out-of-frame human IgVH genes.

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Article

Base-specific sequences that bias somatic hypermutation deduced by analysis of out-of-frame human IgVH genes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1998

Dunn-Walters D K, Dogan A, Boursier L, MacDonald C M, Spencer J

Abstract excerpt

Somatic hypermutation introduces mutations into IgV genes during affinity maturation of the B cell response. Mutations are introduced nonrandomly, and are generally targeted to the complementarity determining regions (CDRs). Subsequent selection against mutations that result in lower affinity or...

Topics

Adenine
Base Composition
Cytosine
Genes, Immunoglobulin
Guanine
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Molecular Sequence Data
Mutation
Reading Frames
Regulatory Sequences, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 9498777

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9498777-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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