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Article

Evolution of Ig DNA Sequence to Target Specific Base Positions Within Codons for Somatic Hypermutation

1 Mar 2002

Abstract excerpt

Ig variable (V) region genes are subjected to a somatic hypermutation process as B lymphocytes participate in immune reactions to protein Ags. Although little is known regarding the mechanism of mutagenesis, a consistent hierarchy of trinucleotide target preferences is evident. Analysis of trinucleotide regional distributions predicted and we now empirically confirm the surprising finding that the framework 2...

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Identifiers

PMID: 11859119
DOI: 10.4049/jimmunol.168.5.2302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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