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Article

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.

Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1993

Betz A G, Rada C, Pannell R, Milstein C, Neuberger M S

Abstract excerpt

We have analyzed somatic hypermutation in mice carrying an immunoglobulin kappa transgene in order to discriminate mutations that reflect the intrinsic specificity of the hypermutation mechanism from those highlighted by antigenic selection. We have immunized animals with three different immunogens. With one immunogen, the antigen-specific B cells express a transgenic kappa chain, which does not form part of the...

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Identifiers

PMID: 8460148
DOI: 10.1073/pnas.90.6.2385
PMCID: PMC46091

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