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Article

Characteristics of sequences around individual nucleotide substitutions in IgVH genes suggest different GC and AT mutators.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1999

Spencer J, Dunn M, Dunn-Walters D K

Abstract excerpt

Somatic hypermutation affects Ig genes during T-dependent B cell responses and is characterized by a high frequency of single base substitutions. Hypermutation is not a completely random process; a study of mutations in different systems has revealed the presence of sequence motifs that target mutation. In a recent analysis of the sequences surrounding individual mutated bases in out-of-frame human IgVH genes, we...

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PMID: 10352276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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