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Article

Characteristics of sequences around individual nucleotide substitutions in IgVH genes suggest different GC and AT mutators.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1999

Spencer J, Dunn M, Dunn-Walters D K

Abstract excerpt

Somatic hypermutation affects Ig genes during T-dependent B cell responses and is characterized by a high frequency of single base substitutions. Hypermutation is not a completely random process; a study of mutations in different systems has revealed the presence of sequence motifs that target mutation. In a recent analysis of the sequences surrounding individual mutated bases in out-of-frame human IgVH genes, we...

Topics

Adenine
Animals
Base Composition
Cytosine
DNA Mutational Analysis
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Genes, Immunoglobulin
Guanine Nucleotides
Humans
Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Variable Region

Mice

Mutation

Nucleotides

Thymine

Source

Identifiers

PMID: 10352276

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-10352276-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Characteristics of sequences around individual nucleotide substitutions in IgVH genes suggest different GC and AT mutators.PMID 10352276Read ↗

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