Does base composition help predispose the complementarity-determining regions of antibodies to hypermutation?

doi:10.1016/s0161-5890(97)00074-6

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Article

Does base composition help predispose the complementarity-determining regions of antibodies to hypermutation?

Molecular immunology - 1 Aug 1997

Padlan E A

Abstract excerpt

A survey of the base usage in genes coding for human antibodies reveals that more (A+T) and less (C+G) are found in the segments coding for the complementarity-determining regions, while the opposite is true for the segments coding for framework and constant regions. The possibility that this bias in base usage may contribute to hypermutation is explored.

Topics

Antibodies
Base Composition
DNA, Complementary
Humans
Immunoglobulin Constant Regions
Immunoglobulin Variable Region
Mutation

Source

Open in PubMed

Identifiers

PMID: 9444975
DOI: 10.1016/s0161-5890(97)00074-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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